عنوان
Design, Synthesis and Characterization of Gold(I) Complexes Containing Allyldiphenylphosphine as Improved Cytotoxic Agents
نویسنده (گان)
Kohi,Maede;Shahsavari,Hamid reza;Fereidoonnezhad,Masood
چکیده مقاله
The chemistry of gold is one of the most remarkable areas in the basic and applied chemistry research. Gold complexes have recently grown increasing attention in the design of new metal-based anticancer drugs in order to overcome the drawbacks of platinum-based chemotherapeutic agents [1]. There have been extensive studies on the therapeutic applications of gold complexes particularly antiproliferative properties against wide range of cancerous cells [2]. Here we present the synthesis, characterization and chemotherapeutic properties of allyldiphenylphosphine gold(I) thiolate complexes of [(PPh2Allyl)Au(SR)], 1a-d, SR = deprotonated form of pyridine-2-thiol (HSpy, 1a), pyrimidine-2 thiol (HSpyN, 1b), thiophenol (HSPh, 1c), benzothiazole-2-thiol (HSbt, 1d) and benzimidazole-2-thiol (HSbi, 1e). The cytotoxic activities of gold(I) complexes have been evaluated against various cancer cell lines by means of the MTT assay (MTT= 3-(4,5-dimethylthiazol-yl)-2,5-diphenyl-tetrazolium bromide). Moreover, the ability of some complexes were evaluated to inhibit the proliferation of human breast cancer cells by measuring cell death via induction of apoptosis (Fig. 1).

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