عنوان
Synthesis of new tetrahydro pyridines catalyzed by Fe3O4@S-doped TiO2 via one-pot multi component Mannich reaction
نویسنده (گان)
Nezami,Zahra;Eshghi,Hossein;Seyedi,Seyed mohammad
چکیده مقاله
Organic reactions promoted by recyclable solid catalysts have attracted much attention for their great economic and environmental importance in the chemical and pharmaceutical industries. Synthesis of highly substituted tetrahydro pyridines has been developed using several approaches such as intramolecular Mannich reaction onto iminium ions. These compounds are biologically active and are important in pharmaceutics [1-3]. In this study, synthesis of new tetrahydropyridines from the one-pot three component Mannich reaction between acetyl acetone, aromatic aldehydes and amines under neat conditions is described. Fe3O4@S-doped TiO2 catalyzed this reaction as an efficient, reusable and heterogeneous catalyst (Scheme 1). Catalyst effect was investigated and the result was that it can both increase the rate of the reaction and purity of products. Design and preparation of Fe3O4@S-doped TiO2 hollow nano spheres, and optimization of the condition of the given reaction in the presence of nano catalyst will be discussed in the congress. Scheme 1 References [1] H. Lu, Z. Luo, R. Wu, H. Cheng, S. Nie, Y. Tang, and Y. Gao, Synthesis, 2015, 47, 1447. [2] H. Eshghi, A. Khojastehnezhad, F. Moeinpour, M. Bakavoli, S. M. Seyedi, and M. Abbasi, RSC Adv., 2014, 4, 39782. [3] M. Rahimizadeh, S. M. Seyedi, M. Abbasi, H. Eshghi, A. Khojastehnezhad, F. Moeinpour, and M. Bakavoli, J. Iran. Chem. Soc., 2014, 12, 839.

متن کامل مقاله