عنوان
Synthesis) perchloropyridin-4-yl)(aryl)methanones
نویسنده (گان)
Abdinasab,Salimeh;Ranjbar-karimi,Reza;Poorfreidoni,Alireza
چکیده مقاله
Perhalogenated aromatic and heteroaromatic compounds are important starting materials for the synthesis of other heterocyclic and macrocyclic compounds. The great number of review articles and monographs for the synthesis and applications of pyridines, reflects the important role of substituted pyridines in organic chemistry, biochemistry, and pharmaceutical chemistry. Many researchers are interested in the reactions of various N, O, S, C, and P nucleophiles with perhalogenated compounds [1]. In this work we investigated the synthesis of (perchloropyridin-4-yl)(aryl)methanones. Firstly we synthesized (perchloropyridin-4-yl)copper reagent from the reaction of 4-iodotetrachloropyridine with Cd and Cu powders, respectively, then followed by reaction with benzoyl chloride derivatives. Products confirmed by IR, 1H-NMR and 13C-NMR spectroscopy data.Perhalogenated heteroaromatic compounds are highly regarded toward nucleophilice reaction and few researches conducted on electrophilic reaction[2].

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