عنوان
Nano-BF3/cellulose as a biodegradable catalyst for synthesis of highly functionalized tetrahydropyridines
نویسنده (گان)
Fazeli-attar,Seyede azita;Mirjalili,Bi bi fatemeh
چکیده مقاله
Tetrahydropyridines (THPs) have been the subject of considerable synthetic efforts because of their potent pharmacological properties including antimalarial [1], and anticancer [2]. Nowadays, chemists prefer to use natural catalysts that can be decomposed in environment. Cellulose as a biopolymer and biodegradable material can be used as support in preparation of different catalysts. In this work, cotton was chosen as a cheap and readily available source for synthesizing of nano-cellulose [3]. Nano-BF3/cellulose is a solid acid and biodegradable catalyst that was prepared via reaction of nano-cellulose and BF3. The structure of this catalyst was studied by FT-IR, FESEM, TEM, XRD, EDS, TGA, XRF and BET. In this research, the synthesis of highly functionalized tetrahydropyridines has developed via a five component reaction of aldehyde, amine and ethyl acetoacetate using nano-BF3/cellulose under solvent-free condition (figure 1). The structures of obtained products were identified by FT-IR, 1H-NMR and 13C-NMR. Some advantages of this protocol are high to good yields, environmentally benign, easy work-up of reaction and moderate reusability of the catalyst.

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