عنوان
Synthesis of pyrazole derivatives via three-component reaction
نویسنده (گان)
Alizadehbami,Farzaneh;Mehrabi,Hossein
چکیده مقاله
The pyrazole cores are one of the most important heterocycles compound, they have been attention in recently years due can be found in many pharmaceutical field (such as the anti-anxiety, antipyretic, analgesic and anti-inflammatory drugs) [1]. Recently, some were reported to have non-nucleoside HIV-1 reverse transcriptase inhibitory activity [2]. Herein, we have developed a highly efficient, catalyst-free and green method for the one-pot three-component synthesis of pyrazole derivatives 4 from Meldrum\\s acid 1, arylglyoxal derivatives 2 and phenyl hydrazine 3 in an environmentally favourable moderate (ethanol) (Fig. 1). The structures of the products were determined by means of IR, 1H NMR, 13C NMR.

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