عنوان
Copper-catalyzed click synthesis of 1,2,3-triazole-linked benzimidazole
نویسنده (گان)
Farkhondeh,Amir;Bakherad,Mohammad;Keivanloo,Ali
چکیده مقاله
Copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, also known as the “click reaction”, has become one of the most important reactions used for the preparation of 1,2,3-triazoles [1]. The 1,2,3-triazoles showed significant antiproliferative against a wide variety of human cancer cell lines, including those that are multidrug resistant [2]. The benzimidazole skeleton is an important class of nitrogen-containing heterocyclic compounds with a significant pharmacological efficiency including the anti-bacterial, and anti-viral properties [3]. On the other hand, when 1,2,3-triazoles and benzimidazole are linked by copper-catalyzed click reactions at the specific ring positions of bi- or tri-heterocyclic containing new molecules, interesting physiological proprieties are observed. Herein, we now wish to investigate a straightforward synthesis of new derivatives of the 1,2,3-triazole-linked benzimidazole via the copper-catalyzed click reactions

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