عنوان
Synthesis of new dithiocarbazate Sn(IV) complex; investigation of the crystalline structure and cytotoxic activity
نویسنده (گان)
Yekke-ghasemi,Zahra;Takjoo,Reza
چکیده مقاله
Metal complexes of ONS ligands derived from S-alkyldithiocarbazates comprise an important class of compounds because of their interesting physical and chemical properties and potentially relevance in biological systems. A new Sn(IV) complex, [SnCl2L.DMSO] (Fig. 1) [L: S-ethyl¬-3-(2-hydroxy¬phenyl)methylene¬dithiocarbazate)], is synthesized and characterized using single crystal X-ray diffraction analysis, mass spectrometry and spectroscopic techniques such as IR, 1H- and 13C-NMR. This compound crystallizes in the triclinic system with P space group. The X-ray diffraction data show that the complex has distorted octahedral structure where the sedtc tridentate ONS ligand is coordinated to the metallic ion via phenolic oxygen, iminic nitrogen, and thioenolate sulfur donor atoms. In this compound the two chlorine atoms are arranged as cis relative to each other (96.81(3)º). H2L ligand and one chlorine atom are located at the equatorial position and the other chlorine atom and DMSO solvent are in the axial position. The adjacent molecules in this compound form dimer with ten-members graph set (10) by a pairwise hydrogen bond H7-C7i···Cl2 (2.819 Å) (Symm. Code i: 2-x, 1-y, 1-z). The dimer formed one-dimensional chain along the ac plane bisector through the C10-H10C···π (3.397 Å) and H12B-C12···Cl2 (2.868 Å) interactions. Moreover, in vitro cytotoxicity of the complex against the MCF-7 (Human Breast cancer cell) and Hela (Human cervical cancer cell) cells was assayed by MMT method. Cytotoxicity study shows that ligand coordination to the metal increases cytotoxic activity relative to the free ligand and the complex has significant activity against human cervical cancer cell line.

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