عنوان
Synthesis of a novel pyridine-2,6-dicarboxamide as a fluorescent chemosensors for recognition of ions
نویسنده (گان)
Rahimi,Hannaneh ;Hosseinzadeh,Rahman ;Tajbakhsh,Mahmoud
چکیده مقاله
Molecular receptors have attracted particular attention during the last decades due to high importance of metal cations and anions complexation in many scopes, e.g. industrial activities, environmental conservation, biochemistry and many others [1]. Ions are essential in nature, but a large amount of them can be harmful to health and environment. Thus molecular receptors (sensors), allowing rapid and selective ion recognition, are highly required. Among molecular receptors, fluorescence sensors appeared so useful for this purpose .To design a fluorescent sensor, a general way is to incorporate a fluorophore and a receptor together. Once the target metal ions bind with the receptors, the electronic structures or the molecular structures of the fluorophores will alter to result in an obvious change in the intensity or wavelength of the emission spectroscopy accordingly [2]. Pyridine-2,6-dicarboxamide-based scaffolds have been extensively used for coordinating varied metal ions. Its believed that the presence of a chelating cavity gives such scaffolds towards metal binding [3]. However, if the chelating cavity could also incorporate with a suitable fluorophore; then scaffolds may offer significant sensing possibilities. In this work, we present pyridine-2,6-dicarboxamide-based fluorescent probe, offering a chelating cavity that is incorporated with fluorenyl moieties as fluorophores (Fig 1). The synthesis of desired fluorescent chemosensor will be reported in details and their structures will be characterized by melting point, 1H NMR, and 13C NMR spectroscopy.

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