عنوان
Guanidine Acetic Acid Functionalized Magnetic Nanoparticles: Recoverable Green Catalyst for Transamidation
نویسنده (گان)
Jadidinejad,Masoumeh;Heydari,Akbar;Kazemi miraki,Maryam;Yazdani,Elahe
چکیده مقاله
In the presence of a catalytic amount of Fe3O4-Guanidine aceticacid (GAA) nanoparticles, efficient transamidation of severalamides with various amines is described under solvent-freeconditions. Fe3O4-Guanidine acetic acid nanoparticles providethe first example of a magnetically recoverable organocatalystfor transamidation in the highest catalytic activity. The catalystcould be simply recycled with the assistance of an externalmagnet and reused for six runs without significant loss of itscatalytic activity. Amides are very important compounds with considerableapplications in both the industrial and academic communities.[1]The amide bond is an important functional group in top sellingdrugs such as valsartan, captopril, diltiazem, lidocaine, bupivacaineand acetazolamide Finally, we have supported guanidineacetic acid on the magnetic nanoparticles without usingany supplemental linkersThe catalyst has been demonstrated to be an efficient catalyst for the transamidation of the transamidation products. But benzamide gives moderate to good yield.We also attempted transimidation completedby reaction between a primary amine with the phthalimide as shown atTable 4. Interestingly,the corresponding transimidation products were obtained in good to excellent yields under solvent free conditions.Also, in the model transamidation reaction, the level ofreusability of this heterogeneous organocatalyst was evaluated.The catalyst could be reused for at least 6 times without anytreatment and the results are depicted in Figure.

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