عنوان
Synthesis of new derivatives of 2-alkynylamino-6-substituted-pyrimidine-5-carbaldehyde catalyzed by Pd-Cu
نویسنده (گان)
Rezaeemanesh,Fateme;Bakherad,Mohammad;Nasrisfahani,Hossein
چکیده مقاله
Pyrimidine derivatives are one of the most broadly distributed groups of natural compounds. Most pyrimidine-trione derivatives have several biological properties such as the anti-tumor, anti-cancer, HIV-1 and HIV-2 protease inhibitors, anti-convulsant, and anti-osteoporosis activities [1]. In the last few decades, the concept of catalyzed cascade reactions has been commenced through the advent of transition metal catalysis. Although many transition metal complexes have been found to efficiently catalyze cascade and sequential reactions, palladium complexes are clearly privileged and of paramount importance [3]. The Sonogashira coupling reaction catalyzed by palladium and copper is a powerful and straightforward method for the construction of arylated internal alkynes [4]. In this study, the reaction of 4-chloro-6-substituted-pyrimidine-5-carbaldehyde with various propargylamines catalyzed by Pd–Cu in the presence of triethyl amine as the base in CH3CN leads to the one-pot formation of novel series of 2-alkynylamino-6-substituted-pyrimidine-5-carbaldehyde in moderate-to-high yields.

متن کامل مقاله