عنوان
4H-benzochromene derivatives catalyzed by KCC-1@SO3H nano heterogeneous solid acid
نویسنده (گان)
Zeinali,Atefeh;Allahresani,Ali
چکیده مقاله
During the last decade, 4H-benzochromene derivatives have received great attention in organic chemistry due to their biological and pharmaceutical properties such as antimicrobial, antiviral, sex pheromone, antitumor, anti-inflammatory, anti-tubercular, and cancer therapy [1]. These compounds were synthesized via multicomponent reaction of aromatic aldehyde with malononitrile and β-naphthol in the presence of various Bronsted and Lewis acids such as methane sulphonic acid, TiCl4, H14 [NaP5W30O110], p-TSA, as well as basic catalysts such as g-alumina, Na2CO3, K2CO3, piperidine, nano sized MgO and NaOH. To overcome some drawbacks like the recovery of catalysts and promote the catalytic efficiency, Bronsted acids are supported on solid material producing heterogeneous solid acid. A KCC-1 silica nanosphere with high surface area, which comes from its fibrous morphology, is an excellent nominee to utilize as a support to design efficient heterogeneous nanocatalysts that would satisfy these conditions [3]. In this study, 4H-benzochromene derivatives were synthesized by multicomponent reaction of aromatic aldehyde with malononitrile and β-naphthol in the presence KCC-1@SO3H in water media at reflux conditions. The results showed that the corresponding products were obtained in excellent yields (90-95%)(fig. 1). The catalyst was reused for several times without lack of activity.

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