عنوان
Synthesis, characterization and molecular docking study of new 4-acetamidoalkyl pyrazoles as B-raf /COX-2 inhibitors
نویسنده (گان)
وفايي شعرباف,آسيه;Davoodnia,Abolghasem;Bozorgmehr,Mohamadreza;Pordel,Mahdi
چکیده مقاله
Some new 4-acetamidoalkyl pyrazoles were synthesized by efficient, one-pot three-component reaction of 3,5-dimethyl-1-phenyl-1H-pyrazole or 3-methyl-1-phenyl-1H-pyrazol-5-ol, aromatic aldehydes and acetonitrile in the presence of chlorosulfonic acid at room temperature. The products were characterized on the basis of IR, 1H NMR, and 13C NMR data. Because of the presence of the pyrazole moiety in some COX-2 and B-Raf inhibitors [1], [2], in the next part of our investigation, we evaluated the potency of the synthesized compounds against COX-2 and B-Raf proteins using molecular docking study.

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